Formation of an organized Christian community in Pannipitiya began in 1928 when Rev. Fr. Zacharias Dabarera was the parish priest of Kotte parish. Some government servants working in the area and some Catholic families living in the area requested Rev. Fr. Dabarera to have a Holy Mass for them in their area. A private house in the Pannipitiya Moraketiya road belonging to Mr. Henry James Madanayake was made available to celebrate Holy Mass. From 1928 to 1930 Rev. Fr. Felician Fernando who was the secretary to Archbishop helped Rev. Fr. Zacharias Dabarera to celebrate Holy Mass in this house.

        In 1929 Fr. Dabarera and Mr. Henry James Madanayake bought a land called Maragahawatta for the church for a church. A small church with made with Cajuns was the first church of Pannipitiya parish. Gradually a permanent building was put up for the church over the time. Boundaries of the church were extended up to Meegoda over the time. Until 1948 Pannipitiya church was under Kotte Parish and from 1948 Pannipitiya church came under Nugegoda parish. During the period between 1930 to 1955 the Oblate Priests Rev. Fr. Joseph Fernando, Rev. Fr. Georgius, Rev. Fr. Charles Raymond, Rev. Fr. Tisot and Rev. Fr. Lisi have worked in the Pannipitiya church. In 1950 first confirmation service was conducted by His Eminence Thomas Cardinal Cooray.  Maharagama Teacher Training College and the Panagoda Army camp were situated within the area coming under this parish and Catholics of those institutions have contributed for the development of this church.    

Several Religious Congregations have contributed in the progress of Pannipitiya parish. Apostolic Carmel Sisters from Maharagama convent have worked in the Pannipitiya parish from 1958. Franciscan Brothers have worked in this parish from 1961 to 1970 have worked in this parish. They have been running a technical institute in the church premises. In 1970 Dominican sisters started their service in the parish of Pannipitiya.

Another landmark period began in the Pannipitiya church when Rev. Fr. Don Sylvester came to reside at Pannipitiya church in 1956. In 1959 Pannipitiya was declared a new parish and Rev. Fr. Don Sylvester became the first Parish Priest of the Parish. The foundation stone was laid to build a new church in the present location and the work of the church was completed in 1986 and was blessed by His Grace Rt. Rev. Dr. Nicholas Marcus, the Archbishop of Colombo.

Pannipitiya Parish gave birth to two new parishes. Maharagama parish was erected with its two sub-stations, namely Maharagama and Boralasgomuwa. Homagama Parish was erected with its sub-stations Homagama and Dikhatapma.